S. Imipramine can cause drowsiness, so it's often taken at night. These results should serve evidence-based practice and inform patients, physicians, guideline Aug 23, 2023 · Common Remeron side effects include: drowsiness, dizziness; increased appetite; or. Antidepressants approved by the Food and Drug Administration (FDA) to treat OCD include: Fluoxetine (Prozac) for adults and children 7 years and older. It marks the end of menstrual periods and fertility. Aug 2, 2011 · Careful monitoring is needed for adverse effects, particularly in the first month of treatment Because older people with clinical depression have high rates of concurrent medical illness, particularly cerebrovascular disease, they are at high risk of adverse events from most antidepressants. Women should talk to their healthcare provider about the risks of taking antidepressants during pregnancy and after the baby’s birth. You feel happy, calm, and focused when your serotonin levels are normal. Feb 1, 2022 · Bupropion is a unique antidepressant without sexual side effects. Antidepressants can help relieve the symptoms of depression and anxiety. Common SSRIs include fluoxetine, citalopram, sertraline, paroxetine, and escitalopram. Although antidepressants may not cure depression, they can reduce symptoms. The first antidepressant you try may work fine. These risks are small. Sexual problems, including decreased sex drive or ejaculation failure. It makes the bladder muscle relax, while causing the smooth muscles at the bladder neck to contract. Women are twice as likely as men to be on antidepressants even without reporting being depressed. SSRIs usually are an option during pregnancy. Trazodone may be used along with an SSRI. Amitriptyline has the best evidence for use in migraine prevention. e. Postpartum psychiatric disorders. Untreated depression at this time not only exacerbates the course of a depressive illness, but also puts women at increased risk for sleep disorders Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed type of antidepressant. Aug 17, 2023 · Alpha-beta blockers. Oct 13, 2021 · Tricyclic antidepressants (TCAs) are not used as fr. Different antidepressants cause different side effects, but common side effects include nausea, dizziness, weight gain and sexual problems. In some cases, however, antidepressants cause side effects that don't go away. com Jul 15, 2022 · A quick look at the best supplements for depression. We consider that when antidepressant treatment is indicated in women with postpartum depression, they should not be advised to discontinue breastfeeding. Aug 17, 2021 · SSRI antidepressant side effects. Tamoxifen may also be used to reduce the risk of breast cancer in women at high risk for the disease. SNRIs work via both serotonin and norepinephrine and also impact pain pathways. Side effects of antidepressants are usually mild and improve with time. Women who take antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), during pregnancy may worry about whether the medications can cause birth defects. Many antidepressants, such as SSRIs and SNRIs, raise the levels of serotonin in the brain. A low-dose antidepressant for management of hot flashes may be useful for women who can't take estrogen for health reasons or for women who need an antidepressant for a mood Jun 12, 2020 · The trials involved 116,477 patients (mean age of 44 years; 62% women) who had been randomly assigned to one of 21 antidepressant drugs or placebos. Curcumin. Treatments that are recommended include antidepressants and cognitive behavioral May 14, 2024 · SSRIs, such as Prozac and Zoloft, boost serotonin in the brain, SNRIs, such as Cymbalta or Effexor, boost both serotonin and norepinephrine, while Wellbutrin, an atypical antidepressant, works just on norepinephrine and dopamine levels. venlafaxine (some tablets and capsules) Contains gelatin. Jan 19, 2022 · Fortunately, treatment options exist for PMDD. One study found that between 1998 and 2005, nearly The overall meta-analysis included 25,928 individuals, with 24,595 in the efficacy analysis and 24,693 in the acceptability analysis. Feb 1, 2022 · Key points. However, there is only limited evidence on antidepressant efficacy and safety for PND ( Molyneaux 2014 ). Antidepressants are the most commonly prescribed medications for U. But some people will not experience any changes at all. Antidepressants are commonly used to treat anxiety and major depressive disorder (MDD). Paroxetine and sertraline are most likely suitable first-line agents. Risks include high blood pressure for the pregnant person and premature birth. Certain antidepressants related to the class of drugs called selective serotonin reuptake inhibitors (SSRIs) may reduce menopausal hot flashes. A low-dose form of paroxetine (Brisdelle) is the only nonhormone treatment for hot flashes approved by the U. Headache. They generally have fewer side effects than other types of antidepressants. Evidence Summary. Jun 19, 2018 · restlessness. Fluoxetine is not recommended because it has a long half-life, potentially carries a greater risk of seizures and can interact with certain antiepileptics. Curcumin is the main active component in turmeric (Curcuma longa), a golden spice commonly used in Indian The APA recommends antidepressant medication as an initial treatment choice in people with mild, moderate, or severe major depression, and that should be given to all people with severe depression unless ECT is planned. Nearly two-thirds (64%) of the participants were women. Phentermine stimulates the release of neurotransmitters like norepinephrine, which influence the brain's appetite control center. Antidepressants that slow the reuptake of serotonin provide effective treatment for premenstrual dysphoric disorder (PMDD). All medications taken by the mother are secreted into the breast milk. This is not a complete list of side effects and others may occur. There is good news on this front. Bupropion is a unique Jun 7, 2024 · Monoamine oxidase inhibitors are the oldest antidepressants available in the U. For general information about all psychiatric drugs, including information about coming off medication safely, see our pages about psychiatric medication . Like reuptake inhibitors, tricyclics seem to May 31, 2013 · The effect of antidepressants for women with polycystic ovary syndrome. In addition, multiple studies have shown that SSRI and SNRI Oct 26, 2021 · Antidepressants. Some patients taking SSRIs develop insomnia, skin rashes, headaches, joint and muscle pain, stomach upset, nausea, or diarrhea. Depression is the most common mental health problem in the elderly[1] and is associated with a significant burden of illness that affects patients, their families, and communities and takes an economic toll as well. weight gain. Your primary care doctor or psychiatrist can prescribe medications to relieve symptoms. 1 However, given the likelihood of poor functional outcomes and the increased risk of premature death by Mar 1, 2023 · Upset stomach. Dec 12, 2023 · Antidepressants. Selective serotonin reuptake inhibitors are considered the first-line antidepressant option for patients with epilepsy. Save Content. Read more about when antidepressants are used. Your doctor may prescribe amitriptyline or the muscle relaxant cyclobenzaprine to help promote sleep. An antidepressant can already have an effect within one or two weeks. Therefore, systematic evaluation of the effectiveness and safety of antidepressants for women with PCOS is important. REFERENCES. Credit: Secret. Trazodone. For many people, these improve within weeks of starting an antidepressant. Citalopram or sertraline are more appropriate options. Like most antidepressants, side effects include nausea, fatigue, and nervousness. More and more women are taking antidepressants while pregnant to keep their symptoms in check. A previous study has shown that 5. Antidepressants are a common solution. Note how you feel different, whether worse or better. decreased sex drive, impotence, or difficulty having an orgasm. Tricyclic antidepressants, including amitriptyline, can cause additional side effects, such as: blurred vision. Mirtazapine. Food and Drug Administration. If you take antidepressant medications, you may notice some changes in your weight. Antidepressants can cause unpleasant side effects. The prevalence of depression in women with polycystic ovary syndrome (PCOS) is high; a study has shown it to be four times that of women without PCOS. Common sertraline side effects are nausea, diarrhea, indigestion, loss of appetite, increased sweating, shaking or trembling, decreased appetite, inability to ejaculate, and decreased libido. But with so many antidepressants available, which ones are the most effective? Here, we’ll discuss the various types of antidepressants available and how you and your prescriber can decide which one is the best choice for you. Nov 22, 2023 · Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Dec 21, 2023 · Most commonly, antidepressants are tried first. Certain antidepressants related to the class of drugs called selective serotonin reuptake inhibitors (SSRIs) may decrease menopausal hot flashes. Drowsiness. Consequently Jun 12, 2020 · The trials involved 116,477 patients (mean age of 44 years; 62% women) who had been randomly assigned to one of 21 antidepressant drugs or placebos. Ann Pharmacother. Signs and symptoms such as nausea, weight gain or sleep problems can be common initially. Antidepressants can also relieve long-term symptoms of chronic depressive disorder (dysthymia) and chronic depression, and help make them go away completely. However, few studies have Jun 18, 2020 · In other words, antidepressants improved symptoms in about an extra 20 out of 100 people. Note: If you currently take a prescription antidepressant, talk to your doctor before taking any of these supplements or making any changes to your medication schedule. Antidepressants are used widely to treat depression and anxiety disorders in midlife women. Call your doctor for medical advice about side effects. May 15, 2004 · Antidepressant-induced sexual dysfunction. Other antidepressants that have been used to treat hot flashes include: Venlafaxine (Effexor XR) Paroxetine (Paxil, Pexeva) Citalopram (Celexa) Escitalopram (Lexapro) Imipramine (Tofranil) is a tricyclic antidepressant. Citalopram ( Celexa) and escitalopram ( Lexapro) are similar SSRI Tamoxifen is a SERM (selective estrogen receptor modulator) used in women with breast cancer; it reduces the risk of relapse and improves overall survival. Tiredness. 5 h of food counselling over 6-12 wk. Feb 2, 2020 · Selective Serotonin Reuptake Inhibitors (SSRIs) Large trials have established that luteal phase dosing, i. These medicines work similarly to beta blockers. 3 Rates of depression and suicide have increased, primarily among those younger than 25 years. Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders. Jul 20, 2023 · Tricyclic antidepressants (TCAs) include amitriptyline ( Elavil ), desipramine ( Norpramin ), imipramine ( Tofranil ), and nortriptyline ( Pamelor). bulimia (an eating disorder) some physical conditions, including managing long-term pain. 7–11 Agents and doses shown to be effective with luteal dosing are sertraline 50–100mg, fluoxetine 20mg, paroxetine 10–20mg, and escitalopram 10–20mg. doxepin. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy and acceptability in head-to-head trials. They impact serotonin, a neurotransmitter influencing mood, sleep, and more, and they are particularly useful for people who also have depression as well as anxiety. Nov 30, 2021 · Deciding to use an antidepressant as a treatment option is a personal decision involving a collaborative effort with your doctor. constipation Women receiving tamoxifen for the treatment or prevention of breast cancer should be aware of possible drug-drug interactions between tamoxifen and specific antidepressant medications. These problems are usually temporary or mild or both. phobias. SSRIs are a safe and commonly used antidepressant group and work via serotonin. Some are also licensed to treat other conditions, such as: anxiety disorders. If considering medication for older adults with depression, the panel recommends combining it with interpersonal psychotherapy. Which antidepressant is best for you depends on a number of issues, such as your symptoms and any other health conditions you may have. Mar 11, 2019 · Depression is a debilitating disease that has been associated with an increased risk for a variety of cardiovascular disorders, such as diabetes, hypertension, and coronary artery disease, and Nov 20, 2023 · ACOG has released a new set of guidelines for the treatment of PMS and PMDD (Premenstrual dysphoric disorder). Dec 5, 2023 · Certain selective serotonin reuptake inhibitors (SSRIs). Medications and psychotherapy are effective for most people with depression. A more serious potential problem is reduced blood clotting capacity because of a decreased concentration of the neurotransmitter 4 days ago · Antidepressant usage has skyrocketed — up 65% over the last 15 years. Doctors give women antidepressants for lots of off-label, non-depression reasons: pain, insomnia, menopause symptoms, migraines, fibromyalgia and more. For example, antidepressants help treat obsessive-compulsive disorder, social phobia, panic disorder, generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD). Doing your research, learning more about antidepressants, and Fluoxetine (Prozac) and sertraline (Zoloft and Lustral) are two antidepressants often less likely to cause weight gain. Cymbalta is used to treat major depressive disorder in adults. insomnia. Women taking a low dose of the antidepressant escitalopram had fewer and less severe hot flashes than those taking a placebo, a new clinical trial reports. In most cases, the first step is to figure out a schedule for slowly tapering Oct 4, 2019 · Some antidepressants may increase your appetite, resulting in weight gain, while others may cause nausea. $8 at Amazon. 4 Jan 20, 2022 · Learn how to choose the best antidepressant and compare the most effective antidepressants for depression, anxiety, energy, weight loss, and more. Antidepressants are medicines used to treat mental health conditions such as depression and anxiety. Anxiety. Paroxetine (Paxil) for adults only. Prevalence studies suggest that 14% to 20% of the elderly living in the community experience depressive symptoms,[2] with higher 6 days ago · By Mayo Clinic Press Editors. Sexual dysfunction. ©GettyImages. Wellbutrin is just as effective as the most popular class of antidepressants, the SSRIs (Prozac, Paxil May 19, 2021 · Postmenopausal women are at significant risk for depression . Treatment usually includes pharmacological therapy with antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). Anti-seizure drugs. Nortriptyline is an alternative in patients who may not tolerate amitriptyline. The research indicates antidepressant use Mar 8, 2024 · It is often treated with antidepressants, with or without psychotherapy. Serotonin is a neurotransmitter that helps to facilitate chemical messages in the brain and it is thought this helps with the symptoms of depression. Jun 12, 2014 · All antidepressants carry a suicide warning, too, but Dr. [30] Reviews of antidepressants generally find that they benefit adults with depression. Symptoms include headache, muscle pain, disorientation Apr 2, 2022 · About one in five women ages 40 to 59 and nearly one in four women ages 60 and over used antidepressants in the last 30 days during 2015 to 2018, according to the latest data from the National Aug 15, 2023 · Paxil is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Medications. sexual problems, such as erectile dysfunction. Central-acting agents. Fluvoxamine (Luvox) for adults and children 8 years and older. 7% of women are diagnosed with MDD after menopause . Best with omega-3s: Nordic Naturals EPA Xtra May 27, 2024 · Common sertraline side effects. They work by increasing levels of serotonin in the brain. Each drug has different side effects. Jul 11, 2024 · Best Women's Deodorant for Strong Body Odor. Nov 1, 2012 · Fortunately, one antidepressant rarely causes sexual side effects, Wellbutrin (bupropion). These medicines stop the brain from sending signals to the nervous system to speed up the heart rate and narrow the blood vessels. While SSRIs they might initially cause side effects like Jun 12, 2020 · In head-to-head trials, the results showed that seven antidepressants—agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine—were more Oct 14, 2022 · Treatment. Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Duloxetine (Cymbalta) and milnacipran (Savella) may help ease the pain and fatigue associated with fibromyalgia. Talk to your provider if you experience unpleasant side effects. The reality is that most of the antidepressants taken by women today are relatively safe and carry a very low risk to the developing fetus. Antidepressants also have non-FDA-approved, off-label indications. Overview - Antidepressants. equently as SSRIs in women who are breastfeeding because of the risk of overdose and the risk of adverse effects, which include cardiac adverse effects, such as hypotension, arrhythmias and ECG changes, antimuscarinic side effects, and central nervous system effects, such as dizzin. Jul 2, 2020 · Sexual dysfunction is a common side effect of antidepressants, affecting between 58% and 70% of patients treated with these medications. They may recommend adjusting your dose or trying a different medication. Secret Clinical Strength Stress Response Antiperspirant Deodorant . Depression is a mood disorder that is persistent and can last weeks, months or years. Women may also experience sexual side effects such as decreased libido Aug 2, 2011 · Careful monitoring is needed for adverse effects, particularly in the first month of treatment Because older people with clinical depression have high rates of concurrent medical illness, particularly cerebrovascular disease, they are at high risk of adverse events from most antidepressants. Esketamine (Spravato) is a game-changer that works faster and impacts treatment-resistant depression and suicidality. Alternatively, women could refuse medical treatment for a moderate to severe episode. Best with saffron: NOW Saffron 50 mg. 1 Sexual dysfunction has a significant impact on the Phentermine-topiramate (Qsymia) Phentermine works by affecting the central nervous system, leading to appetite suppression and, consequently, weight loss. Call your doctor for medical advice about side Apr 7, 2023 · Sertraline/Zoloft (FDA approved for OCD in children ages 6 and older). Weight Oct 5, 2019 · By Mayo Clinic Staff. administering medication only in the 14 days preceding menses, of SSRIs is an effective treatment for PMDD when compared to placebo. It may be used to treat mixed incontinence, which is a combination of urge and stress incontinence. The World Health Organization ranks it as one of the most common illnesses. He stresses that, no matter what your treatment, tell your doctor immediately if you feel worse or have suicidal thoughts. However, it’s important to discuss your best options with your doctor. Aug 25, 2022 · Serotonin is a hormone that helps control your mood. To compare antidepressants by type, form, half-life or dietary considerations, see our page on comparing antidepressants. Antidepressant medications: a review of the evidence for drug-induced sexual May 26, 2023 · While antidepressants may be the drug of choice for depression, they also have FDA approval as treatments for other medical disorders. When you begin taking an antidepressant, tell your doctor all the news. Diarrhea. Oct 12, 2017 · Antidepressants are not a first-line therapy for mild to moderate common mental disorder, and women who never take antidepressants may, on average, have less severe symptoms, which potentially could exert fewer biological effects. SNRIs are also sometimes used to treat other conditions, such as anxiety disorders and long-term (chronic) pain, especially nerve pain. Sep 9, 2018 · Dietary counselling used as an active control in a trial of problem-focused therapy for the prevention of depression in 122 elderly adults with sub-syndromal depressive symptoms, found a significant and sustained 40% reduction in Beck Depression Inventory scores at two years in participants who received 5. Remeron side effects (more detail) Nov 28, 2022 · But scientists now realize this is not the case. SNRIs incl …. SNRIs may be helpful if you have chronic pain in addition to Antidepressants are psychiatric drugs which are licensed to treat depression. Mar 21, 2019 · Antidepressants are commonly used as migraine preventives. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are a class of medications that are effective in treating depression. However, too much serotonin can lead to symptoms such as: confusion. Nearly half of the studies had recruited Jul 10, 2023 · Choose one that best matches your unique set of symptoms. Choosing the May 25, 2023 · Antidepressants. The sedating effect of TCAs can be beneficial for patients with comorbid insomnia. Pros. Depression can make it hard for a woman to take care of Antidepressant Effective For Hot Flashes. You may report side effects to FDA at 1-800-FDA-1088. It isn’t known why changing the levels of these chemicals in the brain can help ease depression symptoms. May 25, 2023 · Low-dose antidepressants. The amount of drug to which the infant is exposed depends on many factors, including the medication dosage, as well as the infant’s age and feeding schedule Key facts. Some of the common side effects of Lexapro include nausea, diarrhea, headache, dizziness, dry mouth, drowsiness, and difficulty sleeping. Menopause is a transition that affects many women as they approach age 50. May 14, 2021 · Breastfeeding women who are thinking about discontinuing maintenance antidepressant therapy should be encouraged to discuss their concerns with the prescriber in order to avoid any risk of relapse, withdrawal, or other unintended harmful effects. Antidepressants work on several chemicals in the brain (neurotransmitters) that influence mood. This activity Oct 7, 2019 · In this paper, we detail some management strategies for TESD from a clinical perspective, ranging from prevention (carefully choosing an antidepressant with a low rate of TESD) to possible pharmacological interventions aimed at improving patients’ tolerability when TESD is present. An antidepressant for management of hot flashes may be useful for women who can't take estrogen for health reasons or for women who need an antidepressant for a mood disorder. adults 20 to 59 years of age. Second-generation antidepressants (SSRIs, SNRIs or NDRIs) are recommended for older adults due to the reduced risk of side effects and safety in the event of overdose. The most common side effects Jul 5, 2024 · Paroxetine (Paxil, Paxil CR, Pexeva) Sertraline (Zoloft) Vilazodone (Viibryd) Vortioxetine (Trintellix) The most common side effects of SSRIs include: Nausea and vomiting. Studies of women with postpartum depression were excluded. A 2015 systematic review of 18 randomized controlled trials (RCTs) involving women 27 to 78 years of age (N = 3,490) evaluated the effectiveness of SSRIs and SNRIs for the Jun 1, 1996 · Types of atypical antidepressants are: Bupropion. moclobemide (tablets only) nortriptyline (tablets and capsules only) paroxetine (tablets only) trazodone (tablets and capsules only) trimipramine. Paxil is used to treat depression, including major depressive disorder. 1 weeks, and mean sample size per study was 110. 1 However, given the likelihood of poor functional outcomes and the increased risk of premature death by Apr 19, 2023 · Paroxetine ( Paxil, Pexeva) Sertraline ( Zoloft) Older antidepressants include: Amitriptyline ( Elavil) Desipramine ( Norpramin) Doxepin (Deptran, Sinequan) Tranylcypromine ( Parnate) Trimipramine Feb 21, 2018 · All antidepressants were more efficacious than placebo in adults with major depressive disorder. Fluoxetine/Prozac (FDA approved for OCD in children ages 7 and older as well as major depressive disorder for children ages 8 Aug 9, 2010 · Optimal management of perimenopausal depression. Dec 3, 2023 · Common SSRIs include sertraline ( Zoloft), fluoxetine ( Prozac ), citalopram ( Celexa ), and escitalopram ( Lexapro ). They can also be used to treat a number of other conditions, including: Antidepressants are also sometimes used to treat people with long-term (chronic) pain. Essential Reads: What is the Best Antidepressant to Use During Pregnancy? Feb 2, 2024 · Lexapro, also known by its generic name escitalopram, is an antidepressant medication that can cause a range of side effects in women. Introduction. Best with rhodiola: Pure Encapsulations Rhodiola Rosea. Medications designed to treat epilepsy are often useful in reducing certain types of pain. Antidepressants and Pregnancy. Some antidepressants are more likely than others to cause sexual side effects. See full list on goodrx. Jan 26, 2024 · Summary. Dry mouth, diarrhea, and headaches are common as well. May 14, 2024 · Depression is a common problem. Only recently has the perimenopause become recognized as a time when women are at risk for new onset and recurrence of major depression. These include citalopram (Celexa), sertraline (Zoloft), escitalopram (Lexapro) and fluoxetine (Prozac). These drugs alleviate the symptoms of PMDD more quickly than those of major depression, which means that women don't necessarily have to take the drugs every day. dosulepin. Nearly half of the studies had recruited Feb 28, 2024 · A new study reports antidepressant prescriptions for young adults and adolescents increased by nearly 64% from 2020 onward, especially among female teens. The newer antidepressants, such as SSRIs and SNRIs, have fewer side effects, so MAOIs aren’t used as often Mar 20, 2020 · Antidepressants are recommended for the treatment of severe PND, the treatment of moderate PND that has not responded to psychological therapy, and for preventing relapse among women with a history of severe depressive illness ( NICE 2014 ). 2002;36:1577-89. It is also used to treat general anxiety disorder in adults and children who are at least 7 . Antidepressants are a type of medicine used to treat clinical depression. These side effects occurred in 5% or more of patients using this medicine. Potent odor and sweat-fighting ingredients; When discussing the use of antidepressant medications by breastfeeding women, It is somewhat misleading to say that certain medications are “safer” than others. Common examples include selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac), and Sep 25, 2023 · Common Pristiq side effects may include: dizziness, drowsiness, anxiety; increased sweating; nausea, decreased appetite, constipation; sleep problems ( insomnia ); or. Jul 12, 2021 · Once your doctor knows why you want to stop using your antidepressant, they can help you chart the best path forward. Aug 4, 2021 · Side effects to antidepressant medications are common and can impact the prognosis of successful treatment outcome in people with major depressive disorder (MDD). Conclusions: Infant exposure of antidepressants through breast milk is generally low to very low. Jun 6, 2024 · Agitation. Montgomery SA, Baldwin DS, Riley A. Change in sleep habits, including sleepiness or trouble sleeping. more. Osborne says that there is generally no need to taper off medications during pregnancy. Mar 8, 2023 · Hyponatremia (low blood sodium) is a dangerous drop in salt levels in the body, usually experienced by older adults taking antidepressants. Meltzer-Brody S, Howard LM, Bergink V, et al. 1. Dry mouth. Miller says suicide is rare. The mean duration of follow-up was 8. In order to be fully effective, tamoxifen must be metabolized to an active metabolite, endoxifen, by the liver enzyme CYP2D6. Antidepressants are a popular treatment choice for depression. They might be prescribed if you have high blood pressure and are at risk of heart failure. However, many people with depression also benefit from seeing a psychiatrist, psychologist or other mental health professional. pu re iw sc nl lq jr mj wt yi